MAPPING THE BINDING SITES OF THE OPIOID ANTIDOTE

CLIENT

Professor Derek Ng

FORMAT

Print 11x17

Cinema 4D

Adobe Illustrator

DATE

July 2020

AUDIENCE

General, highly educated

PURPOSE

Despite being the only widely used opioid antidote, little is known about how Naloxone functions at the molecular level. In this mock magazine spread, recent research that maps the molecular binding sites of this opioid antidote on the mu opioid receptor and its impact on the development of novel antidote drugs is visualized. The educational goal of this assignment was to acquire, evaluate, and integrate molecular data from multiple sources (PDB, journal articles, UniProt, and PubChem) in order to craft a compelling visual narrative of a biomolecule.

PROCESS

Research

Mind mapping

Research

1/12

REFERENCES

Algera, M. H., Kamp, J., van der Schrier, R., van Velzen, M., Niesters, M., Aarts, L., Dahan, A., & Olofsen, E. (2019). Opioid-induced respiratory depression in humans: a review of pharmacokinetic–pharmacodynamic modelling of reversal. British Journal of Anaesthesia, 122(6), e168–e179. https://doi.org/10.1016/j.bja.2018.12.023

Dahan, A., Aarts, L., & Smith, T. (2010). Incidence, Reversal, and Prevention of Opioid-induced Respiratory Depression. Anesthesiology, 112(1), 226–238. https://doi.org/10.1097/aln.0b013e3181c38c25

Handal, K. A., Schauben, J. L., & Salamone, F. R. (1983). Naloxone. Annals of Emergency Medicine, 12(7), 438–445. https://doi.org/10.1016/s0196-0644(83)80343-6

Huang, W., Manglik, A., Venkatakrishnan, A. J., Laeremans, T., Feinberg, E. N., Sanborn, A. L., Kato, H. E., Livingston, K. E., Thorsen, T. S., Kling, R. C., Granier, S., Gmeiner, P., Husbands, S. M., Traynor, J. R., Weis, W. I., Steyaert, J., Dror, R. O., & Kobilka, B. K. (2015). Structural insights into µ-opioid receptor activation. Nature, 524(7565), 315–321. https://doi.org/10.1038/nature14886

Ke, Y. Y., Huang, Y. H., Chien, W. C., Loh, H. H., Chuang, J. Y., & Yeh, S. H. (2017). Mapping the naloxone binding sites on the mu-opioid receptor using cell-based photocrosslinkers. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 1865(3), 336–343. https://doi.org/10.1016/j.bbapap.2016.12.010

Magazine template found at <a href="https://www.freepik.com/psd/mockup">Mockup psd created by user17882893 - www.freepik.com</a>